Abstract
Background Adipocyte fatty acid-binding protein (A-FABP) plays essential roles in lipolysis, insulin resistance, and atherosclerosis. This study aimed to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) in peritoneal dialysis (PD) patients. Methods This study obtained fasting blood samples from 76 PD patients. A validated tonometry system was used to measure cfPWV. Patients with cfPWV values >10 m/s were classified into the high arterial stiffness group, whereas patients with values ≤10 m/s were classified into the low arterial stiffness group, according to the ESH-ESC 2013 guidelines. Serum A-FABP levels were measured using a commercial enzyme-linked immunosorbent assay kit. Results Twenty-five (32.9%) of the 76 PD patients were classified in the high arterial stiffness group. Compared with the patients in the low arterial stiffness group, the high arterial stiffness group was older (P = 0.002) and had a longer PD vintage (P = 0.011), higher diastolic blood pressure (DBP, P = 0.036), higher fasting glucose levels (P = 0.012), higher serum C reactive protein levels (P = 0.001), and higher serum A-FABP levels (P < 0.001). A multivariate logistic regression analysis of the factors significantly associated with central arterial stiffness revealed that A-FABP (odds ratio (OR): 1.165, 95% confidence interval (CI): 1.056–1.284, P = 0.002), age (OR: 1.423, 95% CI: 1.153–1.757, P = 0.001), PD vintage (OR: 1.049, 95% CI: 1.015–1.085, P = 0.005), and DBP (OR: 1.152, 95% CI: 1.033–1.285, P = 0.011) were independent predictors of central arterial stiffness in PD patients. Furthermore, serum A-FABP levels (β = 0.476, adjusted R2 change: 0.197, P < 0.001) were significantly positively correlated with cfPWV according to the multivariable forward stepwise linear regression analysis. Conclusions A-FABP levels are an independent marker of central arterial stiffness in PD patients.
Highlights
Arterial stiffness describes the rigidity of an artery and its inability to expand and contract during pressure changes; this condition is a common consequence of diabetes and chronic kidney disease [1, 2]
Two-dimensional scattered plots of Adipocyte fatty acid-binding protein (A-FABP) levels and carotid-femoral pulse wave velocity (cfPWV) values in subgroup analysis with older age, hypertension, diabetes mellitus (DM), gender among these peritoneal dialysis (PD) patients were drawn, which are presented as Figures 2(a)–2(d), respectively
Discussion e main finding of our study suggests that serum A-FABP levels are an independent predictor for arterial stiffness in PD patients after adjusting for other confounders
Summary
Arterial stiffness describes the rigidity of an artery and its inability to expand and contract during pressure changes; this condition is a common consequence of diabetes and chronic kidney disease [1, 2]. Us, the principal purpose of this study was to examine the correlation between arterial stiffness and A-FABP levels in PD patients. Adipocyte fatty acid-binding protein (A-FABP) plays essential roles in lipolysis, insulin resistance, and atherosclerosis. Is study aimed to evaluate the relationship between serum A-FABP levels and carotid-femoral pulse wave velocity (cfPWV) in peritoneal dialysis (PD) patients. Compared with the patients in the low arterial stiffness group, the high arterial stiffness group was older (P 0.002) and had a longer PD vintage (P 0.011), higher diastolic blood pressure (DBP, P 0.036), higher fasting glucose levels (P 0.012), higher serum C reactive protein levels (P 0.001), and higher serum A-FABP levels (P < 0.001). Serum A-FABP levels (β 0.476, adjusted R2 change: 0.197, P < 0.001) were significantly positively correlated with cfPWV according to the multivariable forward stepwise linear regression analysis. A-FABP levels are an independent marker of central arterial stiffness in PD patients
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