Serum β-glucuronidase aktivität in abhängigkeit von geschlecht und alter bei diabetes mellitus

Abstract

With the aid of a modiued method according to Fishman the activity of β-glucuronidase in serum was determined in 97 healthy blood donors. The mean for women was 1317 ± 1244 (±2s) Fishman units and for men 1791 ± 1678 (±2 s) F.u. Examination of 113 serum samples of patients with diabetes mellitus yielded in comparison with normal controls an increase of enzyme activity for men and women independent of the blood sugar values and severity of diabetes mellitus judged by therapy. The mean for 57 men was 2858 F.u. (range 800–16600 F.u.) and for 56 women 2324 F.u. (range 800–5650 F.u.). It is postulated that the increased β-glucuronidase activity in serum of patients with diabetes has to be referred to an insulinindependent metabolic pathway of glucose degradation. Such a pathway is probably the glucuronic acid cycle.