Abstract
It is required to explore the response mechanism of life systems to inorganic nanomaterials for effective, safe and controllable applications of inorganic nanomaterials. The key is to properly understand the nano-bio interface interaction between inorganic nanomaterials and biomolecules under biological conditions. This review mainly discussed the gold and silver nanomaterials which can enhance the Raman intensity at the nano-bio interface. We introduced the research process of the applications of the surface-enhanced Raman scattering (SERS) to in situ study biomolecules such as nuclei acids, proteins and lipids absorbed on the surface or interface of gold, silver and other inorganic nanomaterials as well as the interactions between the nanomaterials surface or interface and biological systems such as cells, viruses and bacteria. The applications of SERS method in the exploring of the interaction mechanisms between biological system and inorganic nanomaterials (mainly gold and silver nanomaterials) interface, the detecting of biomolecules, and the measuring of surface behavior of biomolecules were summarized.
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