Abstract
The aim of the present study was to evaluate visual acuity (VA) and central macular thickness (CMT) to assess the influence of serous retinal detachment (SRD) in eyes with macular edema (ME) secondary to branch retinal vein occlusion (BRVO). Sixty-one eyes with BRVO from 61 patients with ME were analyzed and divided into two groups according to the spectral domain optical coherence tomography (OCT) findings of SRD and cystoid macular edema (CME). All patients underwent complete ophthalmic examinations and OCT measurements (Cirrus, Carl Zeiss Meditec Inc, Dublin, CA). Patients with marked retinal hemorrhage, diabetic retinopathy, previous laser photocoagulation, and/or intravitreal injection were excluded. The mean age of included patients (37 males, 24 females) was 65.4 ± 11.4 (53-77) years. There were 21 patients with SRD and 40 patients with CME. All of the 21 patients with SRD had CME. VA was significantly worse in the SRD group compared with the CME (non-SRD) group (0.82 ± 0.34 logMAR vs 0.64 ± 0.38 logMAR; P=0.005). Conversely, CMT was significantly greater in the SRD group than in the CME group (465 ± 115 µ vs 387 ± 85 µ; P=0.00004). SRD may be associated with decreased VA. The prognosis of patients with BRVO and SRD requires further investigation.
Highlights
Branch retinal vein occlusion (BRVO) is the second most common retinal vascular disorder after diabetic retinopathy[1,2]
Optical coherence tomography (OCT) studies have demonstrated that macular edema secondary to BRVO is frequently associated with cystoid macular edema (CME), serous retinal detachment (SRD), and inner retinal thickening
SRD is a common feature on OCT images, there is a lack of data regarding the influence of SRD on visual acuity (VA), central macular thickness (CMT), and response to therapies in BRVO patients
Summary
Branch retinal vein occlusion (BRVO) is the second most common retinal vascular disorder after diabetic retinopathy[1,2]. In BRVO, increased intravascular pressure causes dysfunction of the endothelial blood-retinal barrier, resulting in increased vascular permeability, eventually leading to cystoid macular edema (CME). Macular edema is the most frequent cause of visual loss in patients with BRVO. Optical coherence tomography (OCT) studies have demonstrated that macular edema secondary to BRVO is frequently associated with CME, serous retinal detachment (SRD), and inner retinal thickening. The mechanism underlying SRD has yet be fully elucidated, extensive leakage of fluid from capillaries in the ischemic retina affected by BRVO may lead to accumulation in the subretinal space and cause serous detachment[9]. Studies have demonstrated that SRD and the loss of the photoreceptor layer leads to damage to the retinal pigment epithelium and neurosensory retina, contributing to the poor visual prognosis of BRVO[10,11,12]
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