Abstract
The present study explored the effects of p-chlorophenylalaline (p-CPA-300, 200, 100, 50 mg/kg) and 5-hydroxytryptophan (5-HTP-15, 40, 60, 70, 95, 125, 175 mg/kg) upon the aversive threshold of the rat using the spatial preference technique. p-CPA had no reliable effects on the aversive threshold or upon motor activity as measured by this technique. 5-HTP, on the other hand, significantly raised the aversive threshold to moderate levels under the 95- and 125-mg/kg dosages, while motor activity was reduced under the 60-, 70-, 95- and 125-mg/kg dosages. p-CPA (200 mg/kg) was able to block both the increased thresholds and reduced motor activity noted after 125 mg/kg of 5-HTP. These results were interpreted to suggest that modulation of serotonergic activity has little effect upon the aversive threshold of the rat.
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