Abstract
The present study explored the effects of ACTH (4, 12, 24 units), dexamerhasone (.10, .50, 1.0 mg/kg) and deoxycorticosterone (.5, 1.0, 2.0 mg/kg) upon the aversive threshold of the rat using the spatial preference technique. Both ACTH and dexamethasone reduced the mean aversive threshold during the initial presentation of the compound, but only dexamethasone produced decrements that were statistically reliable. Subsequent administration of these two substances, however, produced no reliable effects upon the aversive threshold. The various doses of deoxycorticosterone produced no consistent changes in the threshold to electric shock. None of the substances were able to reliably alter motor activity on this test. These results were interpreted to suggest that the above acute changes in adrenocortical activity have little prolonged effects upon the aversive threshold to grid shock in the rat.
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