Year-end Sale % OFF 
Abstract
Toxoplasmosis is caused by infection with the parasite Toxoplasma gondii. It is one of the most common parasitic infections in humans and is most typically asymptomatic. However infection in a pregnant woman can cause severe and disabling disease in the developing fetus. The presented study aimed to determination the correlation of Toxo-IgA seroprevalence among pregnant women to various Toxoplasma antigens with the serum IL-4 level. From the June 2017 to January 2018, 300 pregnant women enrolled in this study attended to hospitals, primary health care centers and some private medical laboratories in Kirkuk. The pregnant women were examined for Toxo-IgA and determine their specificity for various Toxoplasma antigens by using line immune assay and the serum IL-4 evaluated by using ELISA technique. The rates of Toxo-IgA seropositive were 22 (7.33 %). Considering the reactivity of determined Toxo-IgA against various Toxoplasma antigens; the rates were 12(54.54%), 13(59.09%), 11(50.00%), 14(63.63%), 17(77.27%), 13(59.09%), 11(50.00%) and 18(81.81%) seropositive for Toxoplasma ROP1C, MIC3, GRA7, GRA8, p30, MAG1, GRA1 and rSAG1 antigens respectively. Regarding to the total serum IL-4 level, the highest rate of decreased serum IL-4 level among Toxo-IgA seropositive was 59.09%.In the presented study we concluded the highest rates of decreased serum IL-4 levels was 54.55% seen within Toxo-IgA seropositive for GRA7 and GRA1 antigens , and the rates of increased serum IL-4 level ranged from 5.88% to 9.09% within all seropositive groups to various Toxoplasma antigens.
Highlights
The Toxoplasma gondii (T. gondii) is one of the most successful parasites in the world due to its ability to infect and persist in most warm-blooded animals [1,2]
The infection by toxoplasmosis due to the exposure to the main sources of infection which are: soil, water or food contaminated with feces from infected cats that contain T. gondii oocysts; or raw or uncooked meat that contain bradyzoit cysts [3,4], and vertically transmission may during pregnancy, blood transfusion, and organ transplantation [5]
Monthly prenatal serological screening is performed for all pregnant women whether or not they are considered at risk for T. gondii infection [9, 10]
Summary
The Toxoplasma gondii (T. gondii) is one of the most successful parasites in the world due to its ability to infect and persist in most warm-blooded animals [1,2]. The T. gondii infection during pregnancy can have devastating consequences in the fetus ranging from miscarriage, stillbirth, hydrocephalus, and ocular damage [6] and may lead to late sequelae in the life of the infected newborn [7]. Primary infection with T. gondii acquired during gestation may lead to miscarriage or severe sequelae in the fetus [8]. It is important to screen these particular populations for T. gondii infection in order to take appropriate measures. Monthly prenatal serological screening is performed for all pregnant women whether or not they are considered at risk for T. gondii infection [9, 10]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
