Abstract
Despite the high coverage of prophylactic vaccine against Bordetella pertussis infection in many countries for more than three decades, pertussis remains a common vaccine-preventable disease. Infections have been detected more commonly in countries using acellular pertussis vaccine in their Expanded Program of Immunization. Thailand implemented a routine infant immunization program with whole-cell pertussis vaccine in 1977, and since 1992, the national vaccine policy has offered a five-dose whole-cell pertussis vaccine for children given at the ages of 2, 4, 6, 18, and 48 months. This study aimed to investigate the seroprevalence of antibodies to pertussis toxin among healthy people across all ages to determine the level of whole-cell vaccine-induced immunity in the population, and to identify which age group should be targeted for a booster dose. The lowest seronegative rate and highest geometric mean concentrations were found in the 0–10 years age group, corresponding to their recent pertussis vaccination. The proportion of people with undetectable IgG level was prominent, starting after 11 years of age onwards. Now that a reduced-dose pertussis vaccine with fewer adverse effects is available, a booster dose during adolescence should be considered in order to reduce the incidence of pertussis disease. Further studies exploring how long the reduced-dose pertussis vaccine can provide protective immunity against pertussis disease when administered to adults and adolescents should also be performed.
Highlights
Pertussis is a contagious bacterial disease of the respiratory tract characterized by a severe protracted paroxysmal cough that sometimes ends with a whooping sound, known as “whooping cough.” It is caused mainly by Bordetella pertussis and is spread by direct contact with or breathing the aerosolized secretions of infected individuals
The highest geometric mean concentrations (GMC) was found in the 0–10 years age group (GMC 12.81 IU/ml, 95% CI = 10.30– 15.91), and the lowest in the 31–40 years age group (GMC 3.76 IU/ml, 95% CI = 2.87–4.93)
The purpose of the current study was to compare the patterns of anti-pertussis toxin IgG across all ages from both the pre- and post-vaccination eras, and to identify the appropriate time for a booster dose
Summary
Pertussis is a contagious bacterial disease of the respiratory tract characterized by a severe protracted paroxysmal cough that sometimes ends with a whooping sound, known as “whooping cough.” It is caused mainly by Bordetella pertussis and is spread by direct contact with or breathing the aerosolized secretions of infected individuals. Pertussis is a contagious bacterial disease of the respiratory tract characterized by a severe protracted paroxysmal cough that sometimes ends with a whooping sound, known as “whooping cough.”. It is caused mainly by Bordetella pertussis and is spread by direct contact with or breathing the aerosolized secretions of infected individuals. Pertussis Antibody after 37 Years of Universal Vaccination in Thailand. Chulalongkorn University (RES560530093), the Outstanding Professor of Thailand Research Fund (DPG5480002), Siam Cement Group, and MK Restaurant Company Limited. All grants were given to Professor Yong Poovorawan. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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