Abstract
BackgroundKaposi sarcoma (KS) is a complex multifocal neoplasm and is the major cause of death for about 50% of acquired immunodeficiency syndrome (AIDS) patients. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus with a causal role in the development of all types of KS. KS is prevalent among the Uygur people in Xinjiang, especially in south area. Here we carried out a cross-sectional study among 1534 general Uygur individuals from south and north region of Xinjiang to assess the seroprevalence of KSHV and to identify the potential correlation between KSHV seroprevalence and KS incidence.ResultsSeroprevalence of KSHV in South and North Xinjiang was 23.1% and 25.9%, respectively. Older age was independently associated with higher KSHV seroprevalence. In subjects from South Xinjiang, lower educational level and reported drinking were each independently associated with higher KSHV seroprevalence. Furthermore, the antibody titer was significantly lower in both south and north KSHV seropositive individuals compared with KS patients, as analyzed by gradient dilution (P < 0.001).ConclusionKSHV is highly prevalent in the general Uygur population in both South and North Xinjiang. Interestingly, the infection rate of KSHV in these two geographical areas did not correlate well with KS incidence. Perhaps unknown factors exist that promote the progression of KSHV infection to KS development in the local minority groups.
Highlights
Kaposi sarcoma (KS) is a complex multifocal neoplasm and is the major cause of death for about 50% of acquired immunodeficiency syndrome (AIDS) patients
Characteristics of the study population and Kaposi’s sarcoma-associated herpesvirus (KSHV) seroprevalence Of the 1534 Uygur people included in the study, 1008 (65.7%) were from the southern part of Xinjiang and 526 (34.3%) were from the northern part of Xinjiang
The lower education associated with KSHV seroprevalence only in south region of Xinjiang
Summary
Kaposi sarcoma (KS) is a complex multifocal neoplasm and is the major cause of death for about 50% of acquired immunodeficiency syndrome (AIDS) patients. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus with a causal role in the development of all types of KS. We carried out a cross-sectional study among 1534 general Uygur individuals from south and north region of Xinjiang to assess the seroprevalence of KSHV and to identify the potential correlation between KSHV seroprevalence and KS incidence. KS can be classified according to its clinical and epidemiological characteristics and the different types include: classical, acquired immunodeficiency syndrome (AIDS)-related, iatrogenic and endemic KS [2,3]. 20% of AIDS patients develop KS in Western countries and AIDS-KS is the major cause of death for KSHV prevalence exhibits considerable variation in different geographical regions and populations.
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