Abstract
An observational study was conducted in a peri-urban dairy establishment in Jos South, Plateau State Nigeria to determine immune response of dairy cattle to commercial inactivated foot-and-mouth disease vaccine serotypes (O and A). Thirty seven Friesian cattle aged ?2years old with their crosses (15 selected pre-vaccination and 22 selected 21 days post-vaccination) were investigated for immune response to vaccination with an inactivated trivalent FMD vaccine containing serotypes O, A and SAT 2). Sera collected on day 0 pre-vaccination and 21 days post-vaccination was tested for structural protein antibodies to FMD serotypes O and A using the Solid Phase Competitive ELISA assay. The mean OD value for serum end point titre of FMD serotype O pre-vaccination was 11.64% with 6.67% (95%CI: 0.33 28.73) of the selected cattle being seropositive, at 21 days post-vaccination the mean OD value in selected cattle was 52.83% with 68.18% (95%CI: 46.95 84.89) of the selected cattle seropositive. For the FMD serotype A, 26.67% (95%CI: 9.10 52.53) of the selected cattle were seropositive pre-vaccination with a mean OD value of 29.21% and by 21 days post-vaccination, 72.73% (95%CI: 51.67 88.13) of the selected cattle were seropositive with a mean OD value of 61.70%. Serological response to vaccination improved in most selected cattle by 21 days post-vaccination. This study result has indicated that commercial inactivated FMD vaccines used for the prophylactic control of FMD in commercial dairy farm in Nigeria provoked immune response after a single shot.Asian J. Med. Biol. Res. June 2015, 1(2): 163-168
Highlights
In Foot-and-mouth disease (FMD) endemic countries, as a prophylactic measure to prevent against outbreaks in susceptible cloven-hoofed farm animals, routine vaccination with inactivated foot-and-mouth disease virus (FMDV) vaccines is recommended (Doel, 2003)
According to the Office International des Epizooties (OIE), FMD vaccines used for the prophylactic control of FMD in endemic settings should be vaccines of standard potency formulated to contain sufficient antigen and appropriate adjuvant to ensure that they meet the minimum potency level required (Elnekave et al, 2013)
In this study we present a preliminary report of serological response of Holstein-Friesian cattle and their crosses vaccinated with inactivated trivalent (O, A and SAT 2) FMD vaccines to antigen for serotypes O and A only
Summary
In Foot-and-mouth disease (FMD) endemic countries, as a prophylactic measure to prevent against outbreaks in susceptible cloven-hoofed farm animals, routine vaccination with inactivated foot-and-mouth disease virus (FMDV) vaccines is recommended (Doel, 2003). According to the Office International des Epizooties (OIE), FMD vaccines used for the prophylactic control of FMD in endemic settings should be vaccines of standard potency formulated to contain sufficient antigen and appropriate adjuvant to ensure that they meet the minimum potency level required (recommended as 3 PD50 [50% protective dose in vaccinated candidates]) (Elnekave et al, 2013). Administering at least 2 doses one month apart when cattle are vaccinated for the first time against FMD with such vaccine is recommended, due to cost and logistical reasons this is not routinely practised in most endemic countries (Knight-Jones et al, 2014a).
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
