Abstract
A number of investigators have observed that, when dogs are treated with diabetogenic anterior pituitary extract, the symptoms of diabetes may make only a transitory appearance despite the daily administration of very large amounts of extract. Young [1937] found that the diabetic condition could be induced to reappear when the amount of extract injected daily was suitably increased, and did not believe that the refractory state resulted from the appearance in the blood of antihormones. However, Dohan & Lukens [1939] found that when a dog had been treated with daily injections of crude anterior pituitary extract for over 9 months, its serum possessed anti-diabetogenic activity. Administration of such serum to completely depancreatized dogs induced a marked decrease in the intensity of glycosuria. Young [1938], on the other hand, using preparations of prolactin with marked glycotropic (anti-insulin) activity, was able to produce sera with marked anti-prolactin action but with no detectable
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