Abstract
Loeb and Bassett1 have shown that an acid extract of cattle anterior pituitary produces hypertrophy of the thyroid gland of guinea pigs. They noted that this experimentally produced hypertrophy characterized by an enlargement of the acinar cells, softening and absorption of colloid, and an irregular and often slit-like shape of the acini, and by the formation of papillary ingrowths into the acini resembles the pathological change in the thyroid gland in Graves disease. In a series of papers from this laboratory this similarity between the effects produced by the injection of extracts of the anterior pituitary gland of cattle and the symptoms of Graves disease has been further emphasized. Loeb and Friedman2 have produced exophthalmos in guinea pigs by repeated intraperitoneal injections of acid extract of the anterior pituitary. Siebert3 showed that this extract produced a rise in metabolism which was counteracted by the administration of potassium iodide, observations which accorded with the depressing ef...
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