Serological and molecular evaluation of parvovirus B19 (B19V) in blood donors from the Blood Center of Brasília, Brazil: focus on women of childbearing age

Nathália F A Silva,Rodrigo Haddad,Allan M Carvalho,Bárbara M S Pimentel,Filipe A C Gonzaga,Daiani Cristina Cilião-Alves,Simone Kashima,Wildo N Araújo,Svetoslav N Slavov

doi:10.5935/1676-2444.20180041

Nathália F A Silva, Rodrigo Haddad + Show 7 more

Open Access

https://doi.org/10.5935/1676-2444.20180041

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Abstract

ABSTRACT Parvovirus B19 (B19V) can be transmitted by the respiratory route, vertically - from the mother to the fetus - and via blood transfusion or organ transplantation. Infection by transfusion of blood or blood products occurs due to the resistance of B19V to viral inactivation methods. Our study evaluated the presence of B19V deoxyribonucleic acid (DNA) and the prevalence of anti-B19V class G immunoglobulin (IgG) in women of childbearing age blood donors of the Federal District, Brazil. Our results demonstrated the absence of B19V DNA in these blood donors. However, the seroprevalence for anti-B19V IgG was observed in 60.7% of this population. This study provides important data of B19V circulation in the Center-West of Brazil.

Highlights

Parvovirus B19 (B19V) can be transmitted by the respiratory route, vertically – from the mother to the fetus – and via blood transfusion or organ transplantation
Our study evaluated the presence of B19V deoxyribonucleic acid (DNA) and the prevalence of anti-B19V class G immunoglobulin (IgG) in women of childbearing age blood donors of the Federal District, Brazil
Our results demonstrated the absence of B19V DNA in these blood donors

Summary

Introduction

Parvovirus B19 (B19V) can be transmitted by the respiratory route, vertically – from the mother to the fetus – and via blood transfusion or organ transplantation. Our study evaluated the presence of B19V deoxyribonucleic acid (DNA) and the prevalence of anti-B19V class G immunoglobulin (IgG) in women of childbearing age blood donors of the Federal District, Brazil. Considering the possibility of B19V transmission by blood transfusion, this study aimed to evaluate the presence of B19V DNA circulating plasma obtained from a group of blood donors from the Blood Center of Brasília, Federal District, Brazil, in women of childbearing age.

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