Serologic Evidence of Exposure to Highly Pathogenic Avian Influenza H5 Viruses in Migratory Shorebirds, Australia.

Michelle Wille,Alice Risely,Aeron C Hurt,Andrew C Breed,Simeon Lisovski,David Roshier,Marta Ferenczi,Marcel Klaassen,Frank Y.K Wong

doi:10.3201/eid2510.190699

Michelle Wille, Alice Risely + Show 7 more

Open Access

https://doi.org/10.3201/eid2510.190699

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Journal: Emerging infectious diseases	Publication Date: Oct 1, 2019
Citations: 25	License type: cc-by

Abstract

Highly pathogenic avian influenza (HPAI) H5Nx viruses of the goose/Guangdong/96 lineage continue to cause outbreaks in poultry and wild birds globally. Shorebirds, known reservoirs of avian influenza viruses, migrate from Siberia to Australia along the East-Asian-Australasian Flyway. We examined whether migrating shorebirds spending nonbreeding seasons in Australia were exposed to HPAI H5 viruses. We compared those findings with those for a resident duck species. We screened >1,500 blood samples for nucleoprotein antibodies and tested positive samples for specific antibodies against 7 HPAI H5 virus antigens and 2 low pathogenicity avian influenza H5 virus antigens. We demonstrated the presence of hemagglutinin inhibitory antibodies against HPAI H5 virus clade 2.3.4.4 in the red-necked stint (Calidris ruficolis). We did not find hemagglutinin inhibitory antibodies in resident Pacific black ducks (Anas superciliosa). Our study highlights the potential role of long-distance migratory shorebirds in intercontinental spread of HPAI H5 viruses.

Highlights

Pathogenic avian influenza (HPAI) H5Nx viruses of the goose/Guangdong/96 lineage continue to cause outbreaks in poultry and wild birds globally
Despite intercontinental spread of gs/GD lineage Highly pathogenic avian influenza (HPAI) H5Nx viruses from Asia to Europe, Africa, and North America, we have no evidence that incursions of these viruses have occurred in Australia
Millions of shorebirds that are reservoirs for avian influenza virus (AIV) migrate from Siberia to Australia, with stopover sites along the coast of East Asia [15,16,17,29]. We demonstrated that these intercontinental migratory birds have been exposed to gs/GD lineage HPAI H5Nx viruses and have the potential to bring these viruses into Australia

Summary

Introduction

Pathogenic avian influenza (HPAI) H5Nx viruses of the goose/Guangdong/96 lineage continue to cause outbreaks in poultry and wild birds globally. Shorebirds, known reservoirs of avian influenza viruses, migrate from Siberia to Australia along the East-Asian-Australasian Flyway. We examined whether migrating shorebirds spending nonbreeding seasons in Australia were exposed to HPAI H5 viruses. We compared those findings with those for a resident duck species. Pathogenic avian influenza (HPAI) A(H5N1) viruses of the goose/Guangdong (gs/GD) lineage emerged in domestic birds in China in 1996, causing high morbidity and mortality rates in poultry; subsequent zoonotic spillover in 1997 caused fatal human infections [1,2]. Unlike HPAI viruses, low pathogenicity avian influenza (LPAI) A viruses are part of the natural virodiversity of wild birds.

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