Sero-Genetical Study among Rural Women of Terai Belt of Bihar, India

Abstract

ABO and Rhesus blood groups are the most important blood groups that are useful for transfusion purposes. The ABO and Rhesus blood groups vary in different populations. Among the several disorders of blood, haemoglobinopathies, Glucose - 6- phosphate dehydrogenase (G-6PD) deficiency and blood group serology are the most important genetic and public health issue in many parts of the world. The present work was undertaken to understand the relationship between blood groups, G-6PD deficiency and sickle cell anaemia. The distribution of ABO blood groups, Rh, G-6PD deficiency and Sickle cell anaemia was studied in rural women populations residing in different villages of Terai belt of Bihar In no case two persons belonging to the same family were subjected to test the above mentioned Mendelian traits. Standard methodology was used to collect data on various parameters. In the present investigation the frequency of blood group was B > O > A > AB. Out of 326 subjects, 141 (43.25%) were of B type, 93 (28.52%) O type, 65 (19.94%) A type and 27 (8.29) were of AB type. The frequency of Rh - was 10.12%. No case of G-6PD deficiency and Sickle cell anaemia was found. The study has a significant implication regarding the management of blood bank and transfusion services in this area. Knowledge of blood group distribution is also important for clinical studies, for reliable geographical information and for forensic studies in the population. The present study revealed a decrease tendency of G-6PD deficiency and sickle cell anaemia in the study area