Serial measurements of blood lactate and early outcome of neonatal hypoxic ischemic encephalopathy after therapeutic hypothermia

Heljic S,Hukeljic L,Terzic S,Spahovic R

doi:10.15761/crt.1000223

Abstract

Serial measurements of blood lactate and early outcome of neonatal hypoxic ischemic encephalopathy after therapeutic hypothermia

Highlights

Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of mortality or neurodevelopmental disability among newborn infants around the world
Initial value of lactate is not proved to be predictive, but prompt decreasing of lactate values within 24 hours of cooling is associated with better early outcome
There is clinical evidence that moderate hypothermia significantly improves survival and disability, including cerebral palsy and neurocognitive outcomes in infants with moderate to severe hypoxic–ischemic encephalopathy at 18 months of age, which persists into middle childhood [2,3,4,5,6,7], it offers only a reduction in risk and requires a high level of neonatal intensive care support, which is not available in many lower resource settings [8]

Summary

Introduction

Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of mortality or neurodevelopmental disability among newborn infants around the world. In term neonates HIE can result in a range of motor and neurodevelopmental disabilities [2,3,4,5]. There is clinical evidence that moderate hypothermia significantly improves survival and disability, including cerebral palsy and neurocognitive outcomes in infants with moderate to severe hypoxic–ischemic encephalopathy at 18 months of age, which persists into middle childhood [2,3,4,5,6,7], it offers only a reduction in risk and requires a high level of neonatal intensive care support, which is not available in many lower resource settings [8]. When full-term neonates suffer asphyxia during labor or delivery, some may develop HIE with outcomes ranging from complete recovery to death. Searching for predictors of outcome can facilitate parental counseling, helping to provide appropriate levels of care

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Discussion

Conclusion