Serial changes in the serum levels of leptin, homocysteine, galectin-3, total phospholipids and hexosamines among patients undergoing coronary artery bypass grafting

Abstract

BackgroundCoronary artery disease (CAD) is the most common cardiovascular disorder in adults. This study was performed to elucidate the role of active leptin, homocysteine, galectin-3, total phospholipids, total, bound, free hexosamines, free-to-bound hexosamines ratio in the pathogenesis of chronic myocardial ischemia and studying the effect of coronary artery bypass grafting (CABG) on their serum levels. MethodsA prospective case control study was carried out on 100 ischemic heart disease male patients undergoing elective CABG and 25 healthy males. Serum levels of total phospholipids, total and free hexosamines, were estimated using spectrophotometric methods, while, serum levels of active leptin, homocysteine and galectin-3 were estimated using ELISA assay kit. ResultsSignificant higher serum active leptin, homocysteine, galectin-3, free hexosamines and free to bound hexosamines ratio levels preoperatively when compared with the control group (p < 0.01 for all) with significant lowering of their serum levels following CABG (p < 0.01 for all) except for active leptin. Significant lower serum total phospholipids, total and bound hexosamines levels preoperatively when compared with the control group (p < 0.01 for all) with significant elevations in their serum levels following CABG (p < 0.01 for all). ConclusionsHigh active leptin, homocysteine, galectin-3, free and free to bound hexosamines ratio and low total phospholipids, total and bound hexosamines play an important role in the pathogenesis of myocardial ischemia. The serum levels of homocysteine, galectin-3, hexosamines and total phospholipids, but not active leptin are significantly lowered following CABG.