Sequential blood purification effects on cardiac function in patients with acute organophosphorus pesticide poisoning

Zhen Liu ,Wenbao Yang ,Shengqiang Yang ,Jinggang Liu ,Jiyin Yuan

doi:10.3760/cma.j.issn.1673-4904.2015.07.005

Zhen Liu , Wenbao Yang + Show 3 more

https://doi.org/10.3760/cma.j.issn.1673-4904.2015.07.005

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Publication Date: Jul 5, 2015

Affiliation: Xian Central Hospital

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Objective To investigate the effects of sequential blood purification on cardiac function in patients with acute organophosphorus pesticide poisoning (AOPP), and to analyze its application value. Methods Forty-five patients with severe AOPP and toxic myocarditis were researched and randomly divided into two groups. Sequential blood purification included hemoperfusion(HP) and continuous veno-venous hemofiltration (CVVH). In treatment group, 23 patients were treated with HP+CVVH on the basis of the conventional therapy. Twenty-two patients of control group received the conventional therapy with HP. The differences of two groups on left ventricular ejection fraction (LVEF) and B-type natriuretic peptide (BNP) were compared before treatment and at 24,48 and 72 h after treatment. Results Before treatment, the levels of LVEF and BNP in treatment group were (47.7±9.8)% and (511.3±285.3) ng/L, in control group were (47.3±10.2)% and (535.4±303.9) ng/L, and there were no significant differences (P>0.05). The levels of LVEF at each time point after treatment in treatment group were significantly higher than those of control group: (52.7±7.3)% vs. (47.8±8.4)%, (55.2±5.2)% vs. (50.6±7.1)%, (60.7±6.3)% vs. (53.3±5.2)%, and the levels of BNP in treatment group were significantly lower than those of control group: (320.7±181.8) ng/L vs. (496.7±268.9) ng/L, (252.7±113.8) ng/L vs. (384.3±167.5) ng/L, (122.4±66.7) ng/L vs. (294.8±121.8) ng/L, there were significant differences between two groups (P 0.05); the levels of LVEF at 48 and 72 h after treatment were significantly increased: (50.6±7.1)%,(53.3±5.2)% vs. (47.3±10.2)%, the levels of BNP were significantly decreased: (384.3±167.5), (294.8±121.8) ng/L vs. (535.4±303.9) ng/L, and there were significantl differences (P<0.05 or<0.01). Conclusion Sequential blood purification treatment of AOPP can reduce myocardial injury and improve the cardiac function. Key words: Poisoning; Cardiac function; Blood purification; Clinical trial

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