Abstract
AbstractThis paper provides a synopsis of statistical methods which can be used for the sequential analysis of possibly censored survival times in clinical trials. Especially, results on the asymptotic behaviour of the Breslow‐Haug statistic and on the sequential version of the logrank statistic are presented in a standardized terminology. In addition, formulae for the explicit calculation of linear and square‐root boundaries for sequential plans are given and illustrated by an example. Practical problems of applying these methods when monitoring a fixed‐sample clinical trial as well as group sequential methods and calculation of P‐values are also discussed.
Published Version
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