Abstract
AbstractCatharanthus roseus is a highly valuable plant often used for its medicinal applications. This plant synthesizes potent antitumor drugs known as vinblastine and vincristine which are produced via monoterpene indole alkaloids (MIAs) biosynthesis pathway. MIA biosynthesis is a complicated pathway that involves about 30 coordinated steps and produces at least 35 intermediates in C. roseus. A combination of recent ‘omics’ studies has created a new means to obtain biologically relevant information about the MIA biosynthesis in C. roseus. However, the availability of the draft genome of C. roseus has expanded our knowledge in understanding the MIA biosynthesis to the next level. The accessibility of genome sequence of C. roseus has also revealed the biochemical processes involved, their regulation and phylogeny of genes responsible for MIA biosynthesis. This chapter presents a summary of the status and future trends in sequencing the genome of C. roseus.Keywords Catharanthus roseus Genome sequencingMIA biosynthesisVinblastineVincristineC. roseus functional genomics database (croFGD)
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