Abstract
A comparison of restriction patterns of human male and female DNA after digestion with Hae III reveals two bands which are present only in male DNA and which are produced by cleavage of repetitive sequences found only on the human Y chromosome (Cooke 1976). Repetitive Y specific sequences can also be detected by exhaustive DNA/DNA hybridization (Kunkel, Smith & Boyer 1976). When DNA from one of these repetitive sequences is isolated as a fragment 3300 bases long from a Hae III digest of male DNA this material can be used as a probe for related sequences in male and female DNA. In both male and female DNA there is DNA which does not contain Hae III sites, which is complementary to this sequence and probably represents related tandem repeats. However, in male DNA fragments which are multiples of 3300 bases long are present showing that this sequence is tandemly repeated.
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