Sequence of an exon of tumour suppressor p53 gene—A comparative study in domestic animals: Mutation in a Feline solid mammary carcinoma

Abstract

Partial sequence determinations were performed on exon 8 of tumour suppressor gene p53 of cattle, sheep, goat, horse and pig. High sequence homology between these species and other species including dog, cat, chicken and man is demonstrated. A mutation CGG-->TGG (arginine-->tryptophan) was detected in a feline solid carcinoma of the mammary gland.