Sequence gene variants in PPARGC1A rs8192678, PPARG2 rs1801282, FTO rs9939609, LEP rs7799039, LEPR rs1137101 and nonalcoholic fatty liver disease

Abstract

Objective: to evaluate the association of sequence variants PPARGC1A rs8192678, PPARG2 rs1801282, FTO rs9939609, LEP rs7799039, LEPR rs1137101 with non-alcoholic fatty liver disease (nAFLD) at young adults in Russian population. Material and methods. The case-control study included 100 patients divided into two groups: group 1 (cases) — with nAFLD (n=50); group 2 (controls) without nAFLD (n=50). All subjects underwent a standard ultrasound examination of the liver and ultrasound shear wave elastography (Aixplorer, France) with an assessment of the severity of liver steatosis and fibrosis. Results. We found two sequence variants associated with an increased risk of nAFLD in women: rs9939609 and rs7799039: A/A rs9939609 genotype (OR 5,33; 95% Cl 1,14-24,90; p=0,041) and G/G genotype rs7799039 (OR 7,5; 95% Cl 1,04-54,12; p=0,026). Conclusion. The A/A genotype ofthe rs9939609 gene in young women in the Russian population increased the chance of having nAFLD by 5 times, the G/G genotype ofthe rs7799039 gene increased the chance of having nAFLD by 7.5 times.