Abstract
Several heterochiral dodecadeoxynucleotides ( 2–6) containing an unnatural L-enantiomer of D-deoxyribose were synthesized and their thermodynamic stability for duplex formation was investigated. The results suggested that substitution of L-deoxyribose for natural D-deoxyribose somewhat decreases the duplex stability, depending on the site that incorporates the L-deoxynucleoside.
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