Abstract
Early recognition of severe sepsis and septic shock, early initiation of effective interventions, implementation of early goal-directed therapy may be key approaches for reducing the mortality and improving the prognosis. This article focused on the staging diagnosis systems for sepsis (PIRO sepsis classification system) and the systematic early warning or rapid response system. We also discussed the diagnostic value of biomarkers, proteomics and metabolomics in sepsis and severe sepsis. No single marker as golden standard has emerged that can provide clinicians with all the information they need for early recognition of sepsis. Therefore, we suggested that clinicians should have even more reason to combine the sepsis symptoms, signs and biomarkers for a comprehensive evaluation, and that they needed to dynamically monitor the changes in these parameters, in order to make reasonable clinical decisions and strategies. Key words: Sepsis; Diagnosis; Screening; Children
Published Version
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