Sepsis prognosis related scoring standards: a comprehensive review

Abstract

: Sepsis is a life-threatening organ dysfunction caused by the dysregulation of the host’s response to infection, whose incidence rate and mortality have been high for a long time. The occurrence and development of sepsis is complex, which is the result of the interaction of many mechanisms and factors. Patients with sepsis often have a hidden onset and are easy to be ignored, resulting in the delay of treatment. Sepsis has long been a focus in the medical world because of its acute onset, high mortality, high consumption of medical resources, while early identification and prevention of sepsis can reduce its mortality. With the deepening of sepsis research, there are numerous scoring systems available for diagnosing and evaluating sepsis at the moment; however, no scoring system can completely and accurately evaluate the prognosis of patients with sepsis. Some scoring systems are too cumbersome, while others limit the time and occasion of use. This review briefly reviewed the composition, development, and clinical validation of those current international scoring systems for sepsis prognosis, to compare their shortcomings and advantages based on the clinical studies. The purpose of this review is to provide further guidance for the selection of prognostic evaluation methods of sepsis.