Sepsis Oluşturmak için Kullanılan Deneysel Hayvan Modelleri

Abstract

Sepsis is a serious condition characterized by an inflammatory condition throughout the body and the presence of a known or suspected infection. The body can improve this inflammatory response by its immune system to microbes in blood, urine, lungs, skin or other tissues. The results of this complex pathophysiology can be monitored in different ways, such as severe hypotension, metabolic acidosis, tissue damage and multiple organ failure, acute respiratory distress syndrome (ARDS) / acute lung injury (ALI), and even death. Despite supportive treatments, antibiotics, immunotherapy agents and new treatment options, sepsis appears to be the most common health problem in intensive care units with a high mortality rate of up to 90%. For this reason, sepsis is known as both one of the most researched diseases in humans and one of the most studied models in experimental animals. At the same time, sepsis and complications related to sepsis are frequently investigated in veterinary medicine, especially in animals such as sheep. In this article, the information will be given about the models used in animals to create sepsis (Sepsis model created by injection of an exogenous toxin such as lipopolysaccharide (LPS), Fecal sepsis models, sepsis model created by infusion or inoculation of exogenous bacteria), both because of the necessity to try and examine the drugs before the clinical trial in animal experiments and as a disease that threatens animal welfare.