Sepsis, a Common Endpoint to Even Non-Infectious Comorbidities, A Single Center Study on 49,107 Patients, at a Tertiary Care Center in India

Abstract

Background & Objectives- Sepsis, is caused by dysregulated host response that leads to multiple organdysfunction. Complications of sepsis being so grave, it becomes important to address it in a communitysetting as sepsis always presents itself as a reason for clinical deterioration of preventable and commondiseases.Methods- Analysis of in-patient records of 49,107 at a tertiary care centre in India were analysed fromyears 2016-2020, to study correlation of sepsis with various comorbidities such as Diabetes, Hypertension,Coronary artery disease, Cerebrovascular accident and Thyroid; and also, to study the death toll occurringdue to sepsis.Results- Sepsis has a higher prevalence in the vulnerable age groups that is > 60 years followed by < 20years of age. Sepsis is observed more in males (56.32%) than females (43.68%). Sepsis was found to havea statistically significant association (P<0.0001) with Diabetes, Hypertension, Coronary artery disease andcerebrovascular accident. 38% of total deaths that occurred in the hospital were due to sepsis. 68.9% ofpatients who died due to sepsis were ICU cases.Interpretations & Conclusions- Septic patients are 9 times more prone to death than non-septic patientsin an Intensive care unit. There is no statistically significant association between thyroid disorder and sepsis(P=0.38). Generally, a researcher would expect diabetes to be a major contributor to sepsis, however ourpaper reports 70% of total septic cases to be non-diabetic ones. Sepsis itself is caused due to microbialinfections but the comorbidities contributing to its prevalence are non-infectious in nature.