Abstract
Graft-versus-host disease (GVHD) can result from transplantation of blood and bone marrow cells into major histocompatibility complex (MHC)-matched recipient mice due to donor T cell recognition of minor histocompatibility antigens (miHA). Graft-versus-leukemia (GVL) responses can be directed to distinct or over expressed leukemia-restricted antigens presented by MHC class I or class II molecules. In addition, donor T cells which are responsible for the induction of GVHD may also mount a GVL effect directed to shared host miHA on tumor cells.
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