Abstract
The anhydrotetracycline and 4-epi-anhydrotetracycline degradation products of tetracycline have been found to separate from tetracycline on a column of Sephadex G-25. The tetracycline elutes as the “fast” component, whereas the degradation products which are not separated from each other elute as the “slow” component. The ease of column preparation, rapidity of analysis, and repetitive use of a single column make the technique a useful screening procedure for gross contamination of tetracycline preparations with anhydro- and 4-epi-anhydrotetracycline degradation products.
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