Abstract
Dibutyryl cyclic AMP stimulated the synthesis of cyclic nucleotide phosphodiesterase (EC 3.1.4.17) but not its protein activator in normal mouse fibroblasts (3T3) and those virally transformed (3T3-SV 40). Stimulation appeared to be at the transcriptional level. These findings indicate that the increase of phosphodiesterase is not accompanied by its activator and that the two proteins are controlled by separate genes.
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