Abstract
A study of the action of oxidative phosphorylation uncouplers on interaction between neutral red and cultures of normal mouse fibroblasts and L tumor cells showed that the former, unlike the latter, are still able to form granules of the dye in the presence of 1· 10−4 M 2,4-dinitrophenol (DNP). Meanwhile p-trifluoromethoxycarbonylcyanide-phenylhydrazone (FCP), another uncoupler of oxidative phosphorylation, inhibits the deposition of granules of the dye both in L tumor cells and in normal mouse fibroblasts. Accumulation of the dye by normal fibroblasts and by L cells is inhibited by both DNP and FCP in concentrations uncoupling oxidative phosphorylation.
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