Abstract
Sensory receptors—design principles revisited
Highlights
Sensory receptors are often part of complex signal transduction cascades
Insect chemoreceptors operate as ionotropic receptors, namely odorant receptors (ORs), ionotropic glutamate-like receptors (IRs), and gustatory receptors (GRs)
Getahun et al (2012) investigate the temporal response dynamics of insect chemoreceptors and demonstrate that olfactory sensory neurons (OSNs) expressing ORs, GRs, or IRs differ in their response kinetics to brief stimuli
Summary
Sensory receptors are often part of complex signal transduction cascades. An ion current through an ionotropic receptor may initiate metabotropic signaling, as well as a metabotropic receptor may downstream affect the function of ion channels. These binding partners are PDZ-domain containing proteins assumed to target Gγ13 to specific subcellular locations or represent parts of the chemosensory signal transduction cascade.
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