Abstract
The rheological conditions operative during spreading of topical preparations on the skin were determined for series of aqecous gels and oil-in-water emulsions. Master curves were derived from the rheological data obtained using a sensory test with a panel of 24 members. Rates of shear varied from 350 to 10,000sec.*, depending on the consistency and the type of preparation being spread. Two preference scoring techniques were used to assess the series of preparations in terms of spreadability. From the preference data, the shearing conditions with optimum patient acceptance potential were derived. An indication is given for the use of such master curves with their preferred regions for the determination of instrumental rheological conditions for use in routine and innovative industrial control procedures. Where relevant, all results were compared with previously reported work on lipophilic formulations.
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