Sensitization peculiarities for children with allergic rhinitis living
 in Magnitogorsk and Beloretsk cities

Abstract

Basis. Allergic rhinitis is a common chronic disease. The significant increase in incidence among children alarms doctors and parents. We have only isolated epidemiological data on the frequency of occurrence, prevalence and morbidity among children of early and preschool age. The allergic rhinitis incidence depends on the patients’ age, residence, atopic heredity, and other factors. Local studies on the spectrum of sensitization have great practical value. The data gathered from region of residence helps to identify and eliminate clinically significant triggers at an early stage and to prevent the development of comorbid diseases and co-conditions.
 The aim is to analyze the sensitization profile of 2–4 years-old children with allergic rhinitis living in two neighboring territories: Magnitogorsk (Chelyabinsk region, Russia) and Beloretsk (Republic of Bashkortostan, Russia).
 Methods and research material 
 We examined 107 children from two to four years old with diagnosed allergic rhinitis. All patients were divided into two groups according residence: 1st group — 71 kids (average age 3,2 ± 0,7 years) from Magnitogorsk (Chelyabinsk region, Russia), 2nd group — 36 kids (average age 3,1 ± 0,8 years) from Beloretsk (Republic of Bashkortostan, Russia). The children were tested for total IgE and eosinophilic cationic protein, specific IgE (sIgE) to house dust mites, allergens of trees, weeds and grasses, epidermal allergens (ImmunoСap, Phadia). The rate of sensitization to sIgE was estimated in kU/l. The scale of antibodies level is from undetectable (less than 0,35) to extremely high (more than 100).
 Results. The received data shows that children in both groups have high sensitization level to cat and dog allergens, as well as to birch pollen. In addition, patients from Beloretsk have significally more confirmed cases of sensitization to house dust mites (genus Dermatophagoides) than ones from Magnitogorsk (р < 0,01).
 Summary. To get more accurate idea of sensitization spectrum and level among regions of Russia, it is necessary to examine local areas and regions of residence. Local detailed information will help to design an algorithm of treatment aimed to prevent severe forms of allergic diseases in a particular region or territory.