Abstract
Staphylococcus aureus is one of the most prevalent human pathogens causing a wide range of bacterial infections. Since the introduction of methicillin as a treatment option, the emergence and subsequent spread of methicillin-resistant Staphylococcus aureus (MRSA) strains has become a global concern. The objective of this study is to determine the prevalence of MRSA isolated from bacterial infections in Abidjan as well as their resistance profile to certain antibiotics. One hundred and twenty-four (124) strains of Staphylococcus aureus from the University Hospital of Cocody and various clinics isolated from various biological products were included in our study. The antibiogram on Mueller-Hinton agar was repeated by testing cefoxitin for the revelation of MRSA. Several other families of antibiotics have also been tested with the aim of observing resistance associated with MRSA. Among the one hundred and twenty-four strains of Staphylococcus aureus analyzed, 75 present, after phenotypic interpretation, a profile of resistance to methicillin (MRSA strains), i.e. 60.48%. These MRSA were isolated from blood culture (26.67%), purulent secretions (44%), urine (14.67%), sperm culture (1.33%), wound (4%), pleural fluid (4%), stool (1.33%) and tip of urinary catheter (4%); and came from neonatology, surgery, pneumology, pediatrics, outpatient, medicine, emergency, rheumatology, ENT, neurology, traumatology and gastroenterology departments. A variable proportion of MRSA strains express resistance to other families of antibiotics including aminoglycosides (23.32%), fluoroquinolones (85.33%), erythromycin (27.64%), clindamycin (24.19%) and tetracycline (20.73%). The increasing prevalence of multidrug-resistant Staphylococcus aureus, limiting the therapeutic options available against this pathogen, has become an issue of concern worldwide. Thus, the establishment of a relevant resistance monitoring policy to better control the circulation of multi-resistant strains is necessary.
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