Abstract
Objective : to assess sensitivity of K. pneumoniae clinical isolates with different levels of antibiotic resistance to commercial bacteriophage preparations. Material and methods . We have performed re-identification and determination of the sensitivity to antibiotics and bacteriophage preparations of 109 K. pneumoniae clinical isolates isolated from patients hospitalized in medical institutions of three regions of Belarus. The presence of carbapenemase genes has been deteсted by real-time PCR. Results . The study has shown awidespread prevalence of extreme antibiotic resistance among K. pneumoniae associated with the production of NDM and OXA-48 carbapenemases and has found an insufficient lytic activity of bacteriophage preparations against K. pneumoniae strains. The preparation «Sextafag», which lysed with a high activity of 28.4% of Klebsiella isolates possessed the widest spectrum of activity. Conclusion . Bacteriophage preparations can be considered as a possible alternative to antibiotics in the treatment of infections caused by extremely antibiotic-resistant K. pneumoniae isolates.It is necessary to supplement the composition of commercial preparations with phage strains that are active against Klebsiella isolates producing carbapenemases.
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