Abstract
Mdz 0., F. Vymola, E. Vrbova: Sensitivity of Herd Strains of Klebsiella pneu moniae to Antibiotics and its Trend. Acta vet. Bmo, 50, 1981: 201-205. Sixty nine strains of KI. pneumoniae of almost exclusively bov~e origin (milk, nostrils, rectum and skin at the base of the udder) were examined and compared with 72 serotype strains of Danish origin isolated in 1955. Our main interest was focused at the contemporary sensitivity to the antibiotics and evaluation of its trend during the past 25 years. In all experiments the disc method was employed, accomplished by the dilution micromethod for determination of the minimum inhibitory concentration of antibiotics in selected experiments. The following results were obtained: 1) From the total number of 30 preparations examined in both groups of KI. pneu moniae strains 14 antibiotics showed no effect (bacitracin, cephaloridine, erythro mycin, fucidine, lincomycin, methicillin, novobiocin, nystatin, oleandomycin, oxa cillin, penicillin, pristinamycin, spiramycin, vancomycin). 2) Therapeutically prospective results were obtained with cephalothin, gentamicin, kanamycin, colistin, neomycin, oxytetracycline, paromomycin, polymyxin B, strep tomycin and tetracycline. Seventy five to 97.2 % of strains were resistant to ampi cillin and carbenicillin. 3) Among sulphonamides (sulphadimidine, sulphamethoxidine and sulphisoxazole), only sulphamethoxidine proved to be effecti~. 4) An increase in resistance in newly isolated strains of KI. pneumoniae as compared to the Danish serotype strains from 1955 was only observed in gentamicin and colistin (and this only with the dilution method); the number of resistant strains increased by 13 and 13.5 %, respectively. Antibiotics, sulfonamides, resistance.
Highlights
Sixty nine strains of KI. pneumoniae of almost exclusively bov~e origin were examined and compared with 72 serotype strains of Danish origin isolated in 1955
2) Therapeutically prospective results were obtained with cephalothin, gentamicin, kanamycin, colistin, neomycin, oxytetracycline, paromomycin, polymyxin B, streptomycin and tetracycline
In Klebsiella infections, the first and especially the third aspects are of importance, as sensitivity of the etiological agent to widely used cephalothin, kanamycin, streptomycin and others oscillates in rather wide range (Bauer and Seeger 1979), and biological experiments in chickens (Smith 1976) indicate an adaptability of Kl. pneumoniae to both chloramphenicol and chemotherapeutic agents trimethoprim and nalidixic acid
Summary
Sixty nine strains of KI. pneumoniae of almost exclusively bov~e origin (milk, nostrils, rectum and skin at the base of the udder) were examined and compared with 72 serotype strains of Danish origin isolated in 1955. In Klebsiella infections, the first and especially the third aspects are of importance, as sensitivity of the etiological agent to widely used cephalothin, kanamycin, streptomycin and others oscillates in rather wide range (Bauer and Seeger 1979), and biological experiments in chickens (Smith 1976) indicate an adaptability of Kl. pneumoniae to both chloramphenicol and chemotherapeutic agents trimethoprim and nalidixic acid. Such conclusions follow from several field studies; e. Braman et al (1973) found out of 46 strains of KI. pneumoniae isolated from bovine mastitis 37 resistant to chlortetracycline, 35 resistant to dihydrostreptomycin and 8 strains resistant to neomycin
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