The characteristics of the minimum inhibitory concentration of antibiotics on pulmonary infections in patients with cystic fibrosis

Abstract

Aim: Research the minimum inhibitory concentrations (MIC) of antibiotics on lung infections in patients with cystic fibrosis (CF). Methods: This study presents an analysis of microbiological examination of sputum in CF patients. Microbiological research was performed with classical methods and apparatus Walkaway-96 (Siemens, Germany), which determines the MIC of antibiotics. The number of CF patients watched at the Cystic Fibrosis Centre in of Moldova is increasing from 43 (2009) to 62 patients (2014). Results: The frequency of lung infections with Ps.aeruginosa in CF patients from Moldova during the last 6 years is 45-62%, in 50-57% is detected S.aureus and in 3 cases – Stenotrofomonas maltofilias , MRSA - 3 cases and Burkholderia cepacia – in 1 adult CF patient. Microbiological research found that 80% of Ps.aeruginosa strains are sensitive to Tobramycin (MIC≤4), 61% to Amikacin (MIC≤16), 50% to Ofloxacin, 70% to Piperacillin /Tazobactam, in 76% to Ceftazidime (MIC≤8). Imipenemes group of antibiotics have high sensitivity (84%) for Ps.aeruginosa with MIC≤4. S.maltofilias strains identified in CF patients were multidrug-resistant, susceptible to levofloxacin, at in one CF child - sensitive to ceftazidime and amikacin. B.cepacia have a good sensitivity to these antibiotics. S.aureus lung infection present standard antibiotic susceptibility and only in 3 patients was confirmed multidrug-resistant MRSA to antibacterial remedies. Conclusion: In CF patients in etiological structure prevail Ps.aeruginosa and S.aureus lung infections with good sensitivity to antibiotics, rarely multidrug-resistant strains of MRSA, St.maltofilias , B.cepacia .