Abstract
Background. Coagulase-negative staphylococci (CNS), primarily Staphylococcus epidermidis, predominate in the normal microflora of the eye. However, due to irrational antibiotic therapy, resistant strains are widely distributed among CNS. Objective. To study the sensitivity of the antibiotic resistant CNS isolates to the antiseptic picloxydine dihydrochloride ("Vitabact"). Methods. Species, sensitivity to antibiotics and antiseptic picloxydine dihydrochloride were determined for 39 isolates of bacteria obtained from the conjunctival swabs. The cells morphology under the influence of antiseptic was studied by electron microscopy. Results. 33 isolates of S. epidermidis (17 sensitive or resistant to drugs of no more than 2 classes of antibiotics and 16 MDR), 2 S. haemolyticus (1 resistant to 2 classes of antibiotics and 1 MDR), 3 S. hominis (1 sensitive and 2 MDR), 1 S. caprae (MDR) were characterized. In vitro tests, the antiseptic picloxydine dihydrochloride showed high efficiency in suppressing the growth of staphylococci regardless of their sensitivity to antibiotics, as well as bactericidal activity at concentration of 31.2 g/ml. In this concentration, the antiseptic had a pronounced destructive effect on the surface structures of bacterial cells. Conclusion. Antiseptic picloxydine dihydrochloride is effective against antibiotic resistant coagulase-negative staphylococci.
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