Abstract
A new spectrophotometric method is developed for the determination of Paracetamol (PCT) and protriptyline HCl (PTP) in pure forms and in pharmaceutical formulations. The experiment involves the use of 3-chloro-7-hydroxy-4-methyl-2H-chromen-2-one as a novel chromogenic reagent for the determination of PCT and PTP. The method is based on the formation of charge transfer complex between the drugs and chromogenic reagent. Beer's law is obeyed in the concentration ranges 10.00–60.00 µg mL−1 for PCT at 545 nm and 40.00–160.00 µg mL−1 for PTP at 468 nm. The molar absorptivity, Sandell, sensitivity, and limit of detection and quantification are also calculated. The method has been successfully applied for the determination of both PCT and PTP in pharmaceutical samples with acceptable results.
Highlights
Paracetamol (PCT), N-(4-hydroxyphenyl)ethanamide is one of the most commonly used home medicine to reduce pain and fever [1] (Figure 1)
In the present work we report 3-chloro-7-hydroxy-4methylcoumarin as a novel reagent for spectrophotometric determination of PCT and protriptyline HCl (PTP) in pure and pharmaceutical formulations (Tablets)
An accurately weighed amount of pure PCT and PTP was dissolved in ethanol and diluted stepwise to get working concentration
Summary
Paracetamol (PCT), N-(4-hydroxyphenyl)ethanamide is one of the most commonly used home medicine to reduce pain and fever [1] (Figure 1) These actions are known, respectively, as analgesic and antipyretic [2]. Protriptyline HCl (PTP) is one of the tricyclic antidepressant [4], chemically known as N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride (Figure 2) It works by blocking the transporters responsible for reuptake of neurotransmitters like norepinephrine and serotonin [5]. UV-VIS spectrophotometry is a simple analytical method for quantitative analysis which provides practical and significant economic advantages over other methods They are of frequent choice for pharmaceutical analyses. In the present work we report 3-chloro-7-hydroxy-4methylcoumarin as a novel reagent for spectrophotometric determination of PCT and PTP in pure and pharmaceutical formulations (Tablets). A convenient aliquot was subjected to the analysis by using proposed method
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