Sensitive Periods of Emotion Regulation: Influences of Parental Care on Frontoamygdala Circuitry and Plasticity.

Abstract

Early caregiving experiences play a central role in shaping emotional development, stress physiology, and refinement of limbic circuitry. Converging evidence across species delineates a sensitive period of heightened neuroplasticity when frontoamygdala circuitry is especially amenable to caregiver inputs early in life. During this period, parental buffering regulates emotional behaviors and stress physiology as emotion regulation circuitry continues to mature. By contrast, disorganized or poor quality caregiving has profound and lasting consequences on the maturation of frontoamygdala circuitry essential for emotion regulation, even following termination of this early life stressor (e.g., adoption from orphanage). This article highlights how interactions between caregiving experiences and the biological state of the developing brain have broad implications for long-term health.