Abstract
A method has been established for studying the dynamic metabolism of tyrosine to its metabolites in humans using a deuterium-labelled amino acid. Phenylalanine-d 5 was administered orally to human subjects (5 mg/kg) and the levels of p-hydroxyphenylacetic acid-d 4, 4-hydroxy-3-methoxyphenylacetic acid-d 3, and 4-hydroxy-3-methoxymandelic acid-d 3 excreted into urine every hour were determined by gas chromatography—negative-ion chemical-ionization mass spectrometry. This method was also applied to some patients with depression and it was possible to detect a slight alteration in the excretion of some compounds compared with the control.
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Schedule a callMore From: Journal of Chromatography B: Biomedical Sciences and Applications
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