Abstract
Wound Repair The skin protects underlying tissues and organs from potentially damaging microbes and other agents. Epithelial integrity must be reestablished after a skin injury that results in a surface break. For this to happen, cells use altered signaling and mechanical cues to trigger the repair process. Kennard and Theriot examined the mechanism of repair after injury to the zebrafish tailfin. By imaging the actin cytoskeleton, they noted different initial wound responses in zebrafish larvae in different environmental conditions. Cells are sensitive to external sodium chloride at the wound site, suggesting that a change in electrical potential is involved. Applying electric fields triggers actin polarization and basal cell migration, even in absence of wounding. Understanding how skin responds to osmotic and electrical changes may lead to methods for tissue repair. eLife 9 , e62386 (2020).
Published Version
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