Senescent Progenitor Cells in the Skin of Patients with Cutaneous Lupus Erythematosus

Karina De Leeuw,Wietske M Lambers,Gilles Diercks,Johanna Westra,Hendrika Bootsma,Sarah Pringle,Frans G.M Kroese,Xiaoyan Wang

doi:10.1016/j.jid.2021.06.022

Karina De Leeuw, Wietske M Lambers + Show 6 more

Open Access

https://doi.org/10.1016/j.jid.2021.06.022

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Abstract

Senescent Progenitor Cells in the Skin of Patients with Cutaneous Lupus Erythematosus

Highlights

IFN-3edriven inflammation, with chronic discoid lupus erythematosus (CDLE) and subacute cutaneous lupus erythematosus (CLE) (SCLE) as frequent subtypes (Wenzel, 2019)
We recently showed increased p16þ cells in a progenitor cell niche in the salivary gland of patients with the autoimmune disease primary Sjogren’s syndrome, the extent of which correlated with hyposalivation and increased salivary gland lymphocytic infiltration (Wang et al, 2020)
In CLE lesions, significantly more p16þ cells per mm2 were detected in all the three layers, whereas for p21þ cells, this was only significant for the basal and suprabasal layer and as a trend for the further differentiated (FD) area (Figure 1b‒g)

Summary

Introduction

IFN-3edriven inflammation, with chronic discoid lupus erythematosus (CDLE) and subacute CLE (SCLE) as frequent subtypes (Wenzel, 2019). We hypothesized that skin progenitor cells of patients with the autoimmune disease CLE may be senescent. In CLE lesions, significantly more p16þ cells per mm2 were detected in all the three layers, whereas for p21þ cells, this was only significant for the basal and suprabasal layer and as a trend for the FD area (Figure 1b‒g).

Results

Conclusion