Abstract
A series of closely related polyoxygenated sterols from the sponge Dysidea etheria was resolved by high-performance liquid chromatography on a β-cyclodextrin column, a stationary phase apparently not used previously for the preparative separation of natural products. Analysis of the chromatographic behavior of the various sterols on the β-cyclodextrin column indicated that formation of an inclusion complex was not the separation mechanism involved in this case. Rather, the comparative analysis suggested that hydrogen bonding between the solute molecules and the hydroxyl groups on the rim of the β-cyclo-dextrin cavities best explained the results observed.
Published Version
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