Abstract
BackgroundThe most time consuming and limiting step in three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) MR image analysis is the demarcation of the left ventricle (LV) from its surrounding anatomical structures. The aim of this study is to implement a semi-automated segmentation algorithm for 3D cine DENSE CMR using a guide point model approach.MethodsA 3D mathematical model is fitted to guide points which were interactively placed along the LV borders at a single time frame. An algorithm is presented to robustly propagate LV epicardial and endocardial surfaces of the model using the displacement information encoded in the phase images of DENSE data. The accuracy, precision and efficiency of the algorithm are tested.ResultsThe model-defined contours show good accuracy when compared to the corresponding manually defined contours as similarity coefficients Dice and Jaccard consist of values above 0.7, while false positive and false negative measures show low percentage values. This is based on a measure of segmentation error on intra- and inter-observer spatial overlap variability. The segmentation algorithm offers a 10-fold reduction in the time required to identify LV epicardial and endocardial borders for a single 3D DENSE data set.ConclusionA semi-automated segmentation method has been developed for 3D cine DENSE CMR. The algorithm allows for contouring of the first cardiac frame where blood-myocardium contrast is almost nonexistent and reduces the time required to segment a 3D DENSE data set significantly.
Highlights
The most time consuming and limiting step in three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) MR image analysis is the demarcation of the left ventricle (LV) from its surrounding anatomical structures
This study presents a semi-automated LV segmentation algorithm for 3D cine DENSE Cardiovascular magnetic resonance (CMR), using a guide point model approach
The guide point modelling approach to segment 3D cine DENSE data shows promising results, offering a significant reduction in the segmentation time required for a 3D data set
Summary
The most time consuming and limiting step in three dimensional (3D) cine displacement encoding with stimulated echoes (DENSE) MR image analysis is the demarcation of the left ventricle (LV) from its surrounding anatomical structures. Techniques include balanced steady state free precession (SSFP) for morphological cine imaging [1,2], myocardial tagging for intramyocardial strain analysis [3,4] and phase contrast velocity encoding for tissue velocity and strain rate imaging [5,6]. Segmentation methods include deformable models [7,8] and a combination of active contours and region based segmentation techniques [9]. In PC velocity encoding CMR, active contour models and the velocity phase data are used to distinguish between myocardium and blood [14]. Techniques for segmenting SSFP images mostly incorporate image processing methods, which include thresholding, edge detection, mathematical morphology, and image filtering [16]. Prior geometric and spatiotemporal information methods are described in [17,18]
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