Abstract
Background and aims: Hypoglycaemia is an important concern for patients with diabetes and physicians when setting glycaemic targets. The Hypoglycaemia Assessment Tool (HAT) study, the largest and most comprehensive of its kind, assessed self-reported hypoglycaemia and associated predictive factors in a global population of patients with insulin-treated diabetes. Materials and methods: HAT was a non-interventional, multicentre, 6-month retrospective and 1-month prospective study of hypoglycaemic events in 24 countries using self-assessment questionnaires and patient diaries (for 28 days) in people aged ≥18 years with type 1 (T1D) or type 2 (T2D) diabetes using insulin for ≥12 months attending routine clinics. Associations between predictive factors and hypoglycaemia were examined using negative binomial regression models adjusted for period and country. Results: 27,585 patients completed the study (Table 1). 83.4% of patients with T1D and 50.8% of patients with T2D experienced ≥1 hypoglycaemic event in the 4 weeks before baseline (51.5 and 16.5 events per patient year). Higher (p < 0.001) incidence rates were reported in the 4 weeks after baseline (73.3 [T1D] and 19.3 [T2D] events per patient year). A greater percentage of patients with T1D vs. T2D reported any (83.0 vs. 46.5%), nocturnal (40.6 vs. 15.9%) or severe (14.4 vs. 8.9) hypoglycaemia in the prospective period. Conclusion: In this large, multinational population of patients (insulin-treated) with T1D or T2D, rates of overall, nocturnal and severe hypoglycaemia were higher than previously published. An increased incidence of overall hypoglycaemia in the prospective study indicated significant under-reporting of hypoglycaemia.
Published Version
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