Abstract
AbstractSummary:We have developed a self‐reticulating polymer based on silanized hydroxypropylmethylcellulose (Si‐HPMC). The aim of this study was to determine whether this Si‐HPMC hydrogel with or without calcium phosphate granules could represent a potential scaffold for bone tissue engineering.This study showed that Si‐HPMC hydrogel didn't affect SaOS‐2 and rat bone marrow cells viability. In addition, SaOS‐2 cells are able to proliferate within Si‐HPMC hydrogel containing or not calcium phosphate granules whereas Rat bone marrow cells proliferate only at the surface of calcium phosphate granules contained within Si‐HPMC hydrogel. Finally, SaOS‐2 cells seeded at the surface of reticulated Si‐HPMC were not able to penetrate the hydrogel, while J774, a macrophage cells line, were able to move into the Si‐HPMC hydrogel. These data indicate that Si‐HPMC is a promissing scaffold for tissue engineering.
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