Self-assembled PEGylated micelles for precise and targeted drug delivery: Current challenges and future directions

Abstract

Amphiphilic block copolymers with polyethylene glycol (PEG) segments self-assemble into nanoscale micelles, captivating researchers with their diverse therapeutic potential. These versatile carriers encapsulate a wide range of cargoes, from hydrophobic drugs and fragile proteins to delicate nucleic acids, surpassing the limitations of conventional delivery systems.Beyond mere cargo capacity, PEGylated micelles offer controlled and targeted release. Precisely designed, they navigate the biological terrain cloaked by PEG, evading immune recognition and delivering payloads directly to target sites. This translates to enhanced efficacy, reduced side effects, and potentially lower therapeutic doses.However, optimizing micelle design for stability and targeted release remains a challenge. Scaling up production and overcoming potential immunogenicity hurdles further complicate the path to clinical translation.Despite these challenges, collaborative efforts between scientists, engineers, and clinicians hold immense promise. By fine-tuning micelle design, improving stability, and ensuring a seamless transition to the clinic, we can unlock the transformative potential of these nanocarriers.Self-assembled PEGylated micelles stand at the forefront of this revolution, whispering the promise of personalized, targeted therapies. With continued research and expert guidance, these versatile nanocarriers hold the key to a new era in healthcare, where precision medicine becomes a reality and patients experience the true meaning of individualized treatment.